NFL Game Summary - Indianapolis at Arizona

Glendale, AZ (SportsNetwork.com) - Larry Fitzgerald caught two touchdown passes from Carson Palmer as the Arizona Cardinals used a 20-point second quarter to beat the Indianapolis Colts by a 40-11 margin.

Fitzgerald caught five passes for 52 yards for the Cardinals (7-4), who have won four in a row since a 3-4 start. Michael Floyd hauled in seven passes for 104 yards.

Palmer completed 26-of-37 passes for 314 yards for Arizona. Rashard Mendenhall carried the ball 13 times for 54 yards and a score.

Bruce Arians faced the Colts for the first time since leaving the team for the head coaching job in Arizona.

Last season, Arians became the Colts' interim head coach after their head coach Chuck Pagano was diagnosed with leukemia. Arians was 9-3 in Pagano's absence and helped Indianapolis to the playoffs one year after it had gone 2-14 while Peyton Manning stood injured on the sidelines. He became the first interim coach to be named the league's coach of the year, and parlayed the success into a four-year deal with the Cardinals in January.

Andrew Luck completed 20-of-39 passes for 163 yards, one touchdown and an interception for the Colts (7-4), who lead the Titans by two games for first place in the AFC South. Tennessee beat Oakland on Sunday.