Dejan Kulusevski will miss Tottenham's Europa League final against Manchester United after undergoing surgery on his knee, dealing a major blow to the club's hopes of ending their trophy drought.

Kulusevski suffered the injury in Sunday's 2-0 loss at home to Crystal Palace after being caught by Marc Guehi and was substituted in the 19th minute.

Spurs boss Ange Postecoglou provided a mixed assessment post-match, but further scans have shown the Swedish playmaker required surgery.

"We can confirm that Dejan Kulusevski suffered an injury to his right patella in our Premier League fixture against Crystal Palace last weekend," a Tottenham statement said.

"Following further specialist consultation, the midfielder has undergone surgery today (Wednesday) and will commence his rehabilitation with our medical staff immediately."

Midfielder James Maddison was last week ruled out for the rest of the season.

Spurs, 17th in the Premier League, take on United, one place above them, in Bilbao on May 21.

Tottenham have not won a trophy since the 2008 League Cup, and have not tasted European glory since winning the UEFA Cup in 1984.