The No. 32 pick of the 2018 NFL Draft rushed for 117 yards on 27 attempts in the 24-21 win while filling in for injured veteran Joe Flacco.
Jackson completed 13 of 19 pass attempts for 150 yards with no touchdowns and one interception on Sunday. He also led the team in rushing and was the first Ravens player to top 100 yards on the ground in a game this season.
His 27 carries were the most a quarterback has recorded in one game since 1970, according to NFL Research. Jackson also became just the fourth quarterback to rush for 117-plus yards and pass for 117-plus yards in the same game, joining Michael Vick, Randall Cunningham, and Colin Kaepernick.
He was the youngest starting quarterback in Ravens history, according to ESPN's Jamison Hensley. Also, for the first time in the NFL's history, five rookie first-round quarterbacks have now started a game in one season.
Jackson, the 2016 Heisman Trophy winner, rushed for 4,132 yards and 50 touchdowns over his three seasons with the Louisville Cardinals.