Madrid - Tony Adams remains without a point in three matches in charge at Granada after Sandro Ramirez's double earned Andalusian rival Malaga a 2-0 win at Nuevo Los Carmenes on Tuesday.
Defeat means Granada could now be relegated as early as Saturday should the club fail to win at Real Sociedad and Leganes beat Las Palmas on Wednesday.
Adams' men remain seven points adrift of safety and have yet to even score since he replaced the sacked Lucas Alcaraz earlier this month.
Former Barcelona winger Ramirez produced the few true moments of quality with a rasping drive from outside the area two minutes into the second half before sealing the victory in stoppage time with his fifth goal in as many games.
Real Sporting de Gijon also failed to give its chances of survival a boost as the club was held 1-1 at home to Espanyol to remain three points adrift of safety.