Two-time champion Andy Murray’s second-round loss to John Isner is his earliest exit from Wimbledon.
The 6-foot-10 American beat Murray 6-4, 7-6 (4), 6-7 (3), 6-4, hitting 36 aces and 82 winners.
Murray had never lost before the third round at the All England Club. The 35-year-old Scot won the Wimbledon title in 2013 and 2016.