NFL Game Summary - Denver at San Diego

San Diego, CA (SportsNetwork.com) - Peyton Manning passed for 330 yards and four touchdowns Sunday and the Denver Broncos held on to get a win under interim head coach Jack Del Rio.

Manning connected with Demaryius Thomas on three of his touchdown passes and Julius Thomas took the other one 74 yards, leading the Broncos to a 28-20 win over the San Diego Chargers in the first of what will likely be several games without coach John Fox.

After Thomas scored three straight touchdowns to help Denver build a 28-6 lead in the third quarter, the Chargers got a pair of touchdowns to make it a game but a final drive ended in a punt.

Manning, who was 25-of-36, helped the Broncos (8-1) kill off the remaining time with a 9-yard pass to Demaryius Thomas on 2nd-and-7.

The veteran quarterback came up limping on the play after Chargers defensive end Corey Liuget tackled him low, but he called a timeout and was able to stay in the game despite the injury.

Demaryius Thomas finished with seven catches for 108 yards, Julius Thomas had three grabs for 96 and Knowshon Moreno rushed for 65 yards on 15 carries.

Del Rio, the Denver defensive coordinator, is serving as interim coach while Fox recovers from successful aortic heart valve replacement. He faced former Broncos offensive coordinator Mike McCoy, who was hired by the Chargers as head coach in January.

Philip Rivers threw for 218 yards with a touchdown pass to Danny Woodhead, and Ryan Mathews carried 14 times for 59 yards and a score for the Chargers (4-5).