Schedule
Louisville
| Date | Opponent | Score/Time | Stadium |
|---|---|---|---|
| Sep. 01 | vs. Murray State | W 21 - 9 | Papa John's Cardinal Stadium |
| Sep. 09 | vs. FIU | L 17 - 24 | Papa John's Cardinal Stadium |
| Sep. 17 | at Kentucky | W 24 - 17 | Commonwealth Stadium |
| Oct. 01 | vs. Marshall | L 13 - 17 | Papa John's Cardinal Stadium |
| Oct. 08 | at North Carolina | L 7 - 14 | Kenan Memorial Stadium |
| Oct. 15 | at Cincinnati | L 16 - 25 | Paul Brown Stadium |
| Oct. 21 | vs. Rutgers | W 16 - 14 | Papa John's Cardinal Stadium |
| Oct. 29 | vs. Syracuse | W 27 - 10 | Papa John's Cardinal Stadium |
| Nov. 05 | at West Virginia | W 38 - 35 | Mountaineer Field |
| Nov. 12 | vs. Pittsburgh | L 14 - 21 | Papa John's Cardinal Stadium |
| Nov. 19 | at Connecticut | W 34 - 20 | Rentschler Field |
| Nov. 25 | at South Florida | W 34 - 24 | Raymond James Stadium |
| Dec. 27 | at North Carolina State | L 24 - 31 | Bank of America Stadium |
