| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Marco Di Vaio | Montreal Impact | 11 | 10 | 866 | 9 | 2 | 0 | 38 | 23 |
| Jack McInerney | Philadelphia Union | 13 | 12 | 1069 | 9 | 5 | 0 | 43 | 17 |
| Claudio Bieler | Sporting Kansas City | 13 | 12 | 1085 | 6 | 3 | 0 | 36 | 14 |
| Mike Magee | LA Galaxy | 10 | 10 | 892 | 6 | 3 | 0 | 36 | 13 |
| Robert Earnshaw | Toronto FC | 12 | 12 | 1045 | 5 | 1 | 0 | 39 | 13 |
| Chris Wondolowski | SJ Earthquakes | 14 | 14 | 1260 | 5 | 3 | 3 | 56 | 21 |
| Will Johnson | Portland Timbers | 13 | 13 | 1170 | 5 | 1 | 2 | 29 | 11 |
| Thierry Henry | NY Red Bulls | 12 | 10 | 958 | 5 | 3 | 1 | 42 | 15 |
| Dominic Oduro | Columbus Crew | 11 | 11 | 930 | 5 | 2 | 0 | 25 | 10 |
| Giles Barnes | Houston Dynamo | 11 | 11 | 810 | 4 | 0 | 1 | 30 | 9 |
| Ryan Johnson | Portland Timbers | 13 | 12 | 979 | 4 | 1 | 4 | 18 | 10 |
| Rodney Wallace | Portland Timbers | 13 | 8 | 793 | 4 | 3 | 2 | 20 | 8 |
| Tim Cahill | NY Red Bulls | 13 | 13 | 1051 | 4 | 3 | 2 | 25 | 7 |
| Alvaro Saborio | Real Salt Lake | 7 | 6 | 565 | 4 | 1 | 1 | 26 | 9 |
| Darlington Nagbe | Portland Timbers | 13 | 13 | 1028 | 4 | 0 | 2 | 31 | 14 |
| Adam Jahn | SJ Earthquakes | 11 | 6 | 614 | 4 | 0 | 0 | 20 | 10 |
| Eddie Johnson | Seattle Sounders | 7 | 7 | 618 | 4 | 1 | 1 | 22 | 10 |
| Diego Fagundez | NE Revolution | 9 | 8 | 634 | 4 | 3 | 0 | 17 | 9 |
| Will Bruin | Houston Dynamo | 11 | 11 | 915 | 4 | 2 | 3 | 29 | 8 |
| Blas Pérez | FC Dallas | 9 | 8 | 728 | 3 | 1 | 0 | 18 | 11 |
| Andrew Driver | Houston Dynamo | 11 | 9 | 802 | 3 | 1 | 1 | 13 | 7 |
| Lamar Neagle | Seattle Sounders | 6 | 5 | 448 | 3 | 1 | 1 | 11 | 7 |
| Fabian Espindola | NY Red Bulls | 12 | 10 | 937 | 3 | 1 | 1 | 25 | 10 |
| Jamison Olave | NY Red Bulls | 12 | 11 | 943 | 3 | 0 | 0 | 6 | 3 |
| Diego Valeri | Portland Timbers | 11 | 11 | 888 | 3 | 0 | 4 | 35 | 14 |
| Camilo | Vancouver Whitecaps | 10 | 6 | 557 | 3 | 0 | 1 | 33 | 15 |
| Kenny Cooper | FC Dallas | 13 | 12 | 958 | 3 | 1 | 1 | 23 | 14 |
| Graham Zusi | Sporting Kansas City | 12 | 12 | 1057 | 3 | 0 | 4 | 23 | 7 |
| Juan Agudelo | NE Revolution | 8 | 5 | 526 | 3 | 0 | 1 | 10 | 5 |
| Jackson | FC Dallas | 12 | 12 | 1044 | 3 | 1 | 2 | 29 | 8 |
