| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Chris Wondolowski | SJ Earthquakes | 12 | 12 | 1080 | 5 | 3 | 3 | 49 | 17 |
| Thierry Henry | NY Red Bulls | 11 | 9 | 868 | 5 | 3 | 1 | 42 | 16 |
| Mike Magee | LA Galaxy | 10 | 10 | 892 | 6 | 3 | 0 | 36 | 13 |
| Robert Earnshaw | Toronto FC | 10 | 10 | 887 | 5 | 1 | 0 | 34 | 11 |
| Diego Valeri | Portland Timbers | 10 | 10 | 798 | 3 | 0 | 4 | 33 | 13 |
| Jack McInerney | Philadelphia Union | 11 | 10 | 890 | 7 | 4 | 0 | 33 | 15 |
| Marco Di Vaio | Montreal Impact | 10 | 9 | 781 | 6 | 2 | 0 | 32 | 19 |
| Claudio Bieler | Sporting Kansas City | 12 | 11 | 995 | 6 | 3 | 0 | 32 | 13 |
| Giles Barnes | Houston Dynamo | 10 | 10 | 767 | 4 | 0 | 1 | 29 | 9 |
| Deshorn Brown | Colorado Rapids | 9 | 7 | 633 | 2 | 1 | 2 | 29 | 9 |
| Darren Mattocks | Vancouver Whitecaps | 9 | 6 | 592 | 2 | 0 | 1 | 28 | 9 |
| Camilo | Vancouver Whitecaps | 9 | 5 | 467 | 2 | 0 | 0 | 28 | 13 |
| Darlington Nagbe | Portland Timbers | 11 | 11 | 904 | 3 | 0 | 2 | 26 | 11 |
| Chris Rolfe | Chicago Fire | 9 | 9 | 782 | 1 | 0 | 0 | 25 | 5 |
| Atiba Harris | Colorado Rapids | 11 | 10 | 910 | 1 | 1 | 1 | 25 | 8 |
| Federico Higuain | Columbus Crew | 10 | 10 | 886 | 2 | 1 | 2 | 24 | 10 |
| Jackson | FC Dallas | 10 | 10 | 868 | 3 | 1 | 2 | 24 | 8 |
| Will Johnson | Portland Timbers | 11 | 11 | 990 | 4 | 1 | 1 | 23 | 9 |
| Alvaro Saborio | Real Salt Lake | 6 | 6 | 537 | 3 | 1 | 1 | 23 | 8 |
| Will Bruin | Houston Dynamo | 10 | 10 | 825 | 4 | 2 | 3 | 23 | 7 |
| Tim Cahill | NY Red Bulls | 12 | 12 | 961 | 3 | 2 | 2 | 22 | 6 |
| Dominic Oduro | Columbus Crew | 10 | 10 | 845 | 4 | 1 | 0 | 22 | 9 |
| Graham Zusi | Sporting Kansas City | 11 | 11 | 967 | 3 | 0 | 4 | 22 | 6 |
| Luis Gil | Real Salt Lake | 11 | 11 | 839 | 2 | 2 | 1 | 21 | 9 |
| Kenny Cooper | FC Dallas | 11 | 10 | 826 | 2 | 1 | 1 | 21 | 12 |
| Dwayne De Rosario | DC United | 7 | 6 | 571 | 1 | 0 | 1 | 21 | 11 |
| C.J. Sapong | Sporting Kansas City | 12 | 8 | 794 | 1 | 0 | 1 | 21 | 8 |
| Felipe Martins | Montreal Impact | 10 | 10 | 822 | 2 | 1 | 2 | 20 | 7 |
| Jairo Arrieta | Columbus Crew | 9 | 6 | 609 | 1 | 0 | 2 | 20 | 6 |
| Fabian Espindola | NY Red Bulls | 11 | 9 | 860 | 3 | 1 | 1 | 20 | 7 |
