| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Jack McInerney | Philadelphia Union | 15 | 14 | 1249 | 10 | 5 | 0 | 49 | 21 |
| Marco Di Vaio | Montreal Impact | 13 | 12 | 1045 | 9 | 2 | 0 | 43 | 23 |
| Mike Magee | Chicago Fire | 12 | 12 | 1069 | 8 | 3 | 0 | 45 | 17 |
| Claudio Bieler | Sporting Kansas City | 15 | 14 | 1265 | 7 | 3 | 1 | 45 | 17 |
| Dominic Oduro | Columbus Crew | 15 | 15 | 1206 | 7 | 2 | 1 | 38 | 14 |
| Robert Earnshaw | Toronto FC | 14 | 14 | 1186 | 6 | 1 | 0 | 44 | 14 |
| Thierry Henry | NY Red Bulls | 14 | 12 | 1138 | 6 | 3 | 1 | 49 | 17 |
| Camilo | Vancouver Whitecaps | 13 | 9 | 808 | 6 | 0 | 2 | 45 | 20 |
| Blas Pérez | FC Dallas | 10 | 9 | 818 | 5 | 1 | 0 | 20 | 13 |
| Chris Wondolowski | SJ Earthquakes | 16 | 16 | 1440 | 5 | 3 | 3 | 57 | 22 |
| Will Johnson | Portland Timbers | 15 | 15 | 1350 | 5 | 1 | 2 | 33 | 12 |
| Darlington Nagbe | Portland Timbers | 15 | 15 | 1208 | 5 | 1 | 2 | 32 | 14 |
| Robbie Keane | LA Galaxy | 6 | 6 | 523 | 5 | 1 | 4 | 18 | 10 |
| Diego Fagundez | NE Revolution | 12 | 11 | 881 | 5 | 3 | 3 | 21 | 11 |
| Kenny Miller | Vancouver Whitecaps | 6 | 5 | 483 | 5 | 3 | 0 | 13 | 7 |
| Juan Agudelo | NE Revolution | 11 | 8 | 780 | 5 | 0 | 1 | 13 | 7 |
| Lamar Neagle | Seattle Sounders | 9 | 7 | 653 | 4 | 2 | 3 | 16 | 8 |
| Olmes Garcia | Real Salt Lake | 9 | 3 | 401 | 4 | 2 | 1 | 15 | 7 |
| Federico Higuain | Columbus Crew | 15 | 15 | 1336 | 4 | 1 | 3 | 50 | 16 |
| Giles Barnes | Houston Dynamo | 13 | 13 | 975 | 4 | 0 | 2 | 34 | 9 |
| Ryan Johnson | Portland Timbers | 14 | 12 | 997 | 4 | 1 | 4 | 20 | 11 |
| Jamison Olave | NY Red Bulls | 14 | 13 | 1108 | 4 | 0 | 0 | 8 | 5 |
| Rodney Wallace | Portland Timbers | 13 | 8 | 793 | 4 | 3 | 2 | 20 | 8 |
| Tim Cahill | NY Red Bulls | 14 | 14 | 1141 | 4 | 3 | 3 | 28 | 8 |
| Alvaro Saborio | Real Salt Lake | 7 | 6 | 565 | 4 | 1 | 1 | 26 | 9 |
| Diego Valeri | Portland Timbers | 13 | 13 | 1045 | 4 | 0 | 4 | 42 | 17 |
| Adam Jahn | SJ Earthquakes | 12 | 7 | 654 | 4 | 0 | 0 | 20 | 10 |
| Eddie Johnson | Seattle Sounders | 8 | 8 | 690 | 4 | 1 | 1 | 22 | 10 |
| Atiba Harris | Colorado Rapids | 15 | 14 | 1181 | 4 | 2 | 1 | 34 | 12 |
| Will Bruin | Houston Dynamo | 13 | 13 | 1095 | 4 | 2 | 4 | 38 | 10 |
