| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Kenny Cooper | Red Bulls | 13 | 11 | 1060 | 11 | 4 | 1 | 38 | 21 |
| Chris Wondolowski | Earthquakes | 12 | 12 | 1080 | 11 | 4 | 3 | 48 | 20 |
| Thierry Henry | Red Bulls | 9 | 9 | 745 | 9 | 2 | 5 | 41 | 20 |
| Maicon Santos | DC United | 13 | 10 | 878 | 7 | 2 | 1 | 44 | 14 |
| Saer Sene | Revolution | 11 | 10 | 793 | 7 | 2 | 2 | 29 | 18 |
| Alvaro Saborio | Real Salt Lake | 14 | 10 | 1000 | 6 | 2 | 1 | 30 | 13 |
| Steven Lenhart | Earthquakes | 11 | 9 | 780 | 5 | 1 | 0 | 28 | 14 |
| Chris Pontius | DC United | 12 | 8 | 709 | 5 | 3 | 1 | 18 | 7 |
| Will Bruin | Dynamo | 11 | 10 | 843 | 5 | 0 | 1 | 31 | 18 |
| Blas Pérez | FC Dallas | 13 | 13 | 1116 | 5 | 0 | 3 | 30 | 14 |
| David Estrada | Sounders FC | 13 | 12 | 993 | 5 | 2 | 0 | 22 | 10 |
| Dwayne De Rosario | DC United | 15 | 15 | 1311 | 5 | 2 | 8 | 44 | 13 |
| Bernardo Corradi | Impact | 10 | 7 | 606 | 4 | 1 | 1 | 13 | 7 |
| Kei Kamara | Sporting Kansas City | 11 | 11 | 990 | 4 | 2 | 2 | 48 | 21 |
| Fabian Espindola | Real Salt Lake | 12 | 11 | 920 | 4 | 2 | 1 | 30 | 13 |
| Alan Gordon | Earthquakes | 6 | 0 | 184 | 4 | 1 | 0 | 10 | 6 |
| Jaime Castrillón | Rapids | 13 | 13 | 1112 | 4 | 2 | 1 | 20 | 9 |
| Hamdi Salihi | DC United | 12 | 8 | 712 | 4 | 0 | 0 | 22 | 13 |
| Gabriel Gómez | Union | 10 | 10 | 817 | 4 | 1 | 0 | 12 | 7 |
| Kris Boyd | Timbers | 12 | 12 | 1061 | 4 | 1 | 1 | 38 | 15 |
| Dominic Oduro | Fire | 12 | 11 | 940 | 4 | 2 | 1 | 26 | 15 |
| Fredy Montero | Sounders FC | 13 | 12 | 1105 | 4 | 1 | 2 | 67 | 24 |
| Omar Cummings | Rapids | 10 | 10 | 812 | 3 | 1 | 1 | 29 | 13 |
| Nick DeLeon | DC United | 10 | 9 | 771 | 3 | 1 | 3 | 16 | 10 |
| Sébastien Le Toux | Whitecaps FC | 12 | 12 | 1080 | 3 | 1 | 1 | 15 | 8 |
| C.J. Sapong | Sporting Kansas City | 10 | 9 | 736 | 3 | 2 | 0 | 21 | 9 |
| Camilo | Whitecaps FC | 9 | 6 | 532 | 3 | 1 | 2 | 20 | 9 |
| Aurélien Collin | Sporting Kansas City | 11 | 11 | 959 | 3 | 1 | 0 | 13 | 4 |
| Robbie Keane | LA Galaxy | 9 | 9 | 810 | 3 | 1 | 2 | 28 | 14 |
| Kamani Hill | Rapids | 10 | 1 | 305 | 3 | 0 | 1 | 12 | 5 |
