| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Jack McInerney | Philadelphia Union | 12 | 11 | 979 | 8 | 5 | 0 | 37 | 16 |
| Claudio Bieler | Sporting Kansas City | 13 | 12 | 1085 | 6 | 3 | 0 | 36 | 15 |
| Mike Magee | LA Galaxy | 10 | 10 | 892 | 6 | 3 | 0 | 36 | 13 |
| Chris Wondolowski | SJ Earthquakes | 13 | 13 | 1170 | 5 | 3 | 3 | 52 | 19 |
| Tim Cahill | NY Red Bulls | 13 | 13 | 1051 | 4 | 3 | 2 | 25 | 7 |
| Thierry Henry | NY Red Bulls | 12 | 10 | 958 | 5 | 3 | 1 | 42 | 15 |
| Aurélien Collin | Sporting Kansas City | 12 | 12 | 1080 | 2 | 2 | 1 | 15 | 5 |
| Marco Di Vaio | Montreal Impact | 10 | 9 | 781 | 6 | 2 | 0 | 32 | 19 |
| Edson Buddle | Colorado Rapids | 5 | 4 | 316 | 2 | 2 | 1 | 7 | 3 |
| Rodney Wallace | Portland Timbers | 12 | 7 | 705 | 3 | 2 | 2 | 17 | 7 |
| Luis Gil | Real Salt Lake | 12 | 12 | 922 | 2 | 2 | 1 | 23 | 10 |
| Diego Fagundez | NE Revolution | 8 | 7 | 544 | 3 | 2 | 0 | 14 | 8 |
| Dominic Oduro | Columbus Crew | 11 | 11 | 930 | 5 | 2 | 0 | 25 | 10 |
| Will Bruin | Houston Dynamo | 11 | 11 | 915 | 4 | 2 | 3 | 29 | 8 |
| Gershon Koffie | Vancouver Whitecaps | 10 | 8 | 711 | 2 | 1 | 2 | 11 | 5 |
| Fabian Castillo | FC Dallas | 12 | 6 | 522 | 1 | 1 | 1 | 11 | 6 |
| Blas Pérez | FC Dallas | 9 | 8 | 728 | 3 | 1 | 0 | 18 | 11 |
| Andrew Driver | Houston Dynamo | 11 | 9 | 802 | 3 | 1 | 1 | 13 | 7 |
| Je-Vaughn Watson | FC Dallas | 9 | 4 | 484 | 1 | 1 | 0 | 4 | 1 |
| Lamar Neagle | Seattle Sounders | 6 | 5 | 448 | 3 | 1 | 1 | 11 | 7 |
| Felipe Martins | Montreal Impact | 10 | 10 | 822 | 2 | 1 | 2 | 20 | 7 |
| Warren Creavalle | Houston Dynamo | 6 | 1 | 211 | 2 | 1 | 1 | 6 | 3 |
| Olmes Garcia | Real Salt Lake | 7 | 3 | 357 | 2 | 1 | 1 | 13 | 5 |
| Lionard Pajoy | DC United | 11 | 8 | 767 | 2 | 1 | 0 | 14 | 4 |
| Matteo Ferrari | Montreal Impact | 8 | 8 | 720 | 1 | 1 | 0 | 2 | 1 |
| Oriol Rosell | Sporting Kansas City | 12 | 12 | 1000 | 1 | 1 | 1 | 8 | 2 |
| Federico Higuain | Columbus Crew | 11 | 11 | 976 | 2 | 1 | 3 | 29 | 11 |
| Javier Morales | Real Salt Lake | 9 | 7 | 691 | 2 | 1 | 2 | 15 | 6 |
| Deshorn Brown | Colorado Rapids | 10 | 8 | 723 | 2 | 1 | 2 | 35 | 12 |
| Russell Teibert | Vancouver Whitecaps | 6 | 5 | 472 | 2 | 1 | 0 | 10 | 4 |
