| Player | Team | GP | GS | MP | G | GWG | A | S | SOT |
|---|---|---|---|---|---|---|---|---|---|
| Kenny Cooper | Red Bulls | 13 | 11 | 1060 | 11 | 4 | 1 | 38 | 21 |
| Chris Wondolowski | Earthquakes | 12 | 12 | 1080 | 11 | 4 | 3 | 48 | 20 |
| Chris Pontius | DC United | 12 | 8 | 709 | 5 | 3 | 1 | 18 | 7 |
| Kei Kamara | Sporting Kansas City | 11 | 11 | 990 | 4 | 2 | 2 | 48 | 21 |
| Fabian Espindola | Real Salt Lake | 12 | 11 | 920 | 4 | 2 | 1 | 30 | 13 |
| Maicon Santos | DC United | 13 | 10 | 878 | 7 | 2 | 1 | 44 | 14 |
| Alvaro Saborio | Real Salt Lake | 14 | 10 | 1000 | 6 | 2 | 1 | 30 | 13 |
| C.J. Sapong | Sporting Kansas City | 10 | 9 | 736 | 3 | 2 | 0 | 21 | 9 |
| Tony Cascio | Rapids | 13 | 12 | 1019 | 2 | 2 | 1 | 32 | 12 |
| Eddie Johnson | Sounders FC | 10 | 7 | 667 | 3 | 2 | 1 | 22 | 4 |
| Jaime Castrillón | Rapids | 13 | 13 | 1112 | 4 | 2 | 1 | 20 | 9 |
| Brad Davis | Dynamo | 9 | 8 | 696 | 2 | 2 | 2 | 15 | 4 |
| Andre Hainault | Dynamo | 8 | 8 | 633 | 2 | 2 | 1 | 8 | 5 |
| Thierry Henry | Red Bulls | 9 | 9 | 745 | 9 | 2 | 5 | 41 | 20 |
| Dominic Oduro | Fire | 12 | 11 | 940 | 4 | 2 | 1 | 26 | 15 |
| Marco Pappa | Fire | 12 | 11 | 883 | 3 | 2 | 3 | 39 | 14 |
| David Estrada | Sounders FC | 13 | 12 | 993 | 5 | 2 | 0 | 22 | 10 |
| Dwayne De Rosario | DC United | 15 | 15 | 1311 | 5 | 2 | 8 | 44 | 13 |
| Saer Sene | Revolution | 11 | 10 | 793 | 7 | 2 | 2 | 29 | 18 |
| Bernardo Corradi | Impact | 10 | 7 | 606 | 4 | 1 | 1 | 13 | 7 |
| Omar Cummings | Rapids | 10 | 10 | 812 | 3 | 1 | 1 | 29 | 13 |
| Javier Morales | Real Salt Lake | 10 | 6 | 587 | 1 | 1 | 3 | 7 | 3 |
| Nick DeLeon | DC United | 10 | 9 | 771 | 3 | 1 | 3 | 16 | 10 |
| Steven Lenhart | Earthquakes | 11 | 9 | 780 | 5 | 1 | 0 | 28 | 14 |
| Zach Scott | Sounders FC | 9 | 8 | 725 | 1 | 1 | 0 | 7 | 2 |
| Sébastien Le Toux | Whitecaps FC | 12 | 12 | 1080 | 3 | 1 | 1 | 15 | 8 |
| Graham Zusi | Sporting Kansas City | 11 | 11 | 955 | 1 | 1 | 6 | 26 | 7 |
| Bernardo Anor | Crew | 8 | 4 | 375 | 1 | 1 | 0 | 4 | 1 |
| Emilio Rentería | Crew | 11 | 9 | 774 | 2 | 1 | 1 | 23 | 7 |
| Justin Morrow | Earthquakes | 13 | 13 | 1170 | 1 | 1 | 0 | 2 | 1 |
